PO-05-026 IMPACT OF LEADLESS PACING ON VENTRICULAR AND VALVULAR FUNCTION

Traditional transvenous pacemakers have been associated with worsening tricuspid valve (TV) function due to lead-related leaflet impingement, as well ventricular dysfunction related electromechanical dyssynchrony from right pacing. The effect of leadless pacing on and valvular has not established. To describe the impact In patients who underwent a pacemaker implant at Duke University Hospital between November 11, 2014 18, 2019 had pre- post-procedure echocardiographic imaging, features before after were assessed. Valvular regurgitation was graded ordinally 0 (none) 3 (severe). Left quantified by left ejection fraction (LVEF) annular plane systolic excursion (TAPSE). Among 54 consecutive patients, mean age 70.1 ± 14.3 years, 44% women, most frequent indication complete heart block (44%). burden 48.6 42.6%. Over follow-up time 28.7 19.8 months, there no change in severity mitral (mean -0.17 1.02, p= 0.24), 0.07 1.15, p=0.64), or aortic 0.11 0.77, p=0.29) (Figure). There significant bi-atrial bi-ventricular chamber size. post-implant decrease LVEF (52.3 9.3 47.9 12.1, p=0.0019) TAPSE (1.8 0.6 1.6 0.4, p=0.0437) (Table). Neither nor correlated location (apical [n=46] vs non-apical septum [n=7]). Overall, 8 (15%) diagnosed pacing-related cardiomyopathy 6 (11%) received an upgrade biventricular pacemaker. Patients experienced post-implant. However, reduction measures both function. These findings may selection versus system pre-existing TR are vulnerable decline